We analyzed: (i) the amount of Aβ fragment material in CP as well as the transporters that move Aβ into and out of CP, (ii) the expression of collagen at transport interfaces within the BCSFB; and (iii) the effects of highly-expressed human AD-linked transgenes on the synthesis of CP functional proteins such as TTR and AQP-1. Here, AQP1 is linked to Alzheimer disease.