In addition, the previously mentioned cytokines IL-1β, TNF-α, IL-8, IL-6 or TGF-β can influence the response to IR, inducing inflammation, cancer cells invasiveness and fibrosis in irradiated tissues, encouraging the hypothesis of the use of specific inhibitors or drugs able to manipulate cytokine pathways, in order to improve radiation research and therapy. The gene discussed is IL6; the disease is cancer.