The authors suggested that the Dex and BTZ combined treatment may effectively eradicate myeloma cells in their native bone marrow microenvironment in patients undergoing oxidative stress-induced therapy, since the Dex treatment effectively reduces IL-6 secretion from irradiated stroma and BTZ has been shown to be effective in blunting IL-6-mediated survival signalling in myeloma cells [42]. This evidence concerns the gene CASC3 and plasma cell myeloma.