However, the percentage of CD3+CD4+T cells was significantly decreased (p = 0.023), and the percentages of CD3+CD8+ and CD4+CD25+T lymphocytes (p = 0.012 and p = 0.002, respectively) were all significantly increased in DLBCL patients at baseline compared to the healthy controls, resulting in a severe inversion of the CD4/CD8 ratio (Table 1). The gene discussed is CD4; the disease is diffuse large B-cell lymphoma.