Furthermore, a significant reduction of the endogenous NIBP expression in cancer cells by lentivirus-mediated NIBP shRNA inhibited TNFα-induced phosphorylation of IKK1/2 and p65, and degradation of IκBα at 5-30 min of TNFα treatment with most dramatic inhibition at 30 min (Fig. 7C). The gene discussed is TNF; the disease is cancer.