AR and posterior cortical atrophy: Proliferation of BPH-1 and NIH3T3 cells was sensitive to HBC at higher concentrations ranging from 75 – 150 μM (data not shown), suggesting that the proliferation of AR-positive androgen-sensitive (LNCaP), as well as castration-resistant (C4-2B and 22Rv1), PCa cells exhibit a greater sensitivity to HBC than do AR-negative cells.