Since CXCR4 expression was associated with Myc/Bcl-2 expression and TP53 mutations, all of which are adverse prognostic factors, multivariate survival analysis of the pathological factors (including CXCR4+, Myc+, Bcl-2+ and TP53 mutations) and the clinical parameters (including IPI, gender, tumor size, and B symptoms) was performed, which indicated CXCR4 was an independent prognostic factor for disease progression (hazard ratio 1.56, 95% confidence interval of rate 1.13-2.46, P= .008. The gene discussed is TP53; the disease is neoplasm.