However, when dissected in the GCB and ABC subtypes, the independent prognostic significance of CXCR4+ was limited to GCB-DLBCL (P= .04 for PFS); in ABC-DLBCL, Myc and Bcl-2 overexpression and TP53 mutations but not CXCR4 expression, independently predicted poorer survival (Table 3). This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.