In the ABC subtype, NF-κB pathway showed opposite regulations: NF-κB activators CARD11 and PIM2 were upregulated, whereas TNFSF12, TNFSF8 and IL12RB were downregulated (Figure 4I, Supplemental Figures 3J-L). The gene discussed is NFKB1; the disease is aneurysmal bone cyst.