AICDA and diffuse large B-cell lymphoma: AICDA, encoding activation-induced cytidine deaminase which mediates somatic hypermutation and class-switch recombination, was upregulated by 2.92 fold in patients with CXCR4+ DLBCL (3.32 fold in ABC-DLBCL and 2.12 fold in GCB-DLBCL, Figures 4F-G).