CXCR4 and diffuse large B-cell lymphoma: In this study, we assessed the surface expression of CXCR4 using immunohistochemistry (IHC) in 743 patients with de novo DLBCL, compared the gene expression profiles and protein expression of biomarkers between CXCR4+ and CXCR4− DLBCLs, and evaluated the prognostic value of CXCR4 expression.