In some patients of our cohort, increased CXCR4 expression may have resulted from reduced degradation, as suggested by decreased expression of UBD/ubiquitin D and the deubiquitinating enzyme CYLD in GCB-DLBCL and decreased E3 ubiquitin-protein ligase MARCH2 in ABC-DLBCL. The gene discussed is CXCR4; the disease is diffuse large B-cell lymphoma.