CXCR4 and diffuse large B-cell lymphoma: We validated the prognostic significance of CXCR4 in an independent DLBCL cohort (n=275) and confirmed that the prognostic significance of CXCR4 was most common in patients with an IPI ≤2, depended on Bcl-2 overexpression in GCB-DLBCL, and had synergy with Myc expression (Supplemental Figure 4).