Likely owing to the significantly reduced CXCL12 expression, which facilitates T cell infiltration and trafficking, the GEP of patients with CXCR4+ DLBCL revealed remarkably lower expression of T-cell and innate immune response biomarkers (MHC class II molecules HLA-DQA1/HLA-DQA2, HLA-DRB1/HLA-DRB4, TRBC1, GIMAP1, FYN, FYB, LCP2, CD3E, SIRPG, C3, LAT, MAF, and SAMHD1 involved in antigen presentation and T cell signaling) indicating worse prognosis [42], and cell adhesion genes. This evidence concerns the gene CXCL12 and diffuse large B-cell lymphoma.