Further multivariate analysis adjusting for clinical factors of the study cohort indicated that CXCR4+ remained as an independent prognostic factor for significantly poorer OS (P= .02) and PFS (P= .03) in the overall DLBCL; However, only in GCB- but not in ABC-DLBCL patients, CXCR4+ expression was as an independent prognostic factor for poorer PFS (P= .025). Here, CXCR4 is linked to aneurysmal bone cyst.