However, only 10.7% CXCR4+ patients showed BM involvement at diagnosis, and the adverse impact of CXCR4 expression in nodal DLBCL is independent of BM involvement, suggesting other malignant consequences besides BM homing ensuing CXCR4 expression in DLCBL. This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.