Although the inverse correlation between CXCR4 surface expression and CXCL12 mRNA levels was independent of Bcl-2/Myc expression status (Supplemental Figures 3A-D), CXCR4+ expression correlated with significantly poorer survival in patients with Bcl-2+ GCB-DLBCL (Figures 3I-J) or Bcl-2− ABC-DLBCL, but not in patients with Bcl-2− GCB-DLBCL or Bcl-2+ ABC-DLBCL (Supplemental Figure 2). This evidence concerns the gene CXCL12 and diffuse large B-cell lymphoma.