EWSR1 and Ewing sarcoma: Most notably, 37% of the 2,322 strongest EWS-FLI1-correlated H3K27ac enhancer peaks overlapped with DNase-hypersensitive sites present only in the one EWS-FLI1 expressing cell line that was part of the DNase dataset (SK-N-MC) and were thus unique to Ewing sarcoma.