Furthermore, recent work indicates that PD033299, which selectively inhibits CDK6, might be efficacious against multiple myeloma (Huang et al., 2012) and MLL-rearranged AML (Placke et al., 2014), malignancies where the pre-leukemic cell of origin is thought to be an HSC. The gene discussed is CDK6; the disease is acute myeloid leukemia.