(4) reported that the signature of active tuberculosis was detectable in 10–20% of asymptomatic individuals diagnosed with latent M. tuberculosis infection [by the IGRA test, an M. tuberculosis specific antigen-stimulated IFN-γ release assay of human blood or the tuberculin skin test (TST)-skin test], although this could be reflective of subclinical tuberculosis at early stages of disease. Here, IFNG is linked to tuberculosis.