BBC3 and cancer: For example, overexpression of anti-apoptotic BCL-2 proteins confers a favorable prognosis in certain cancer types whereas genetic deletion of the pro-apoptotic BH3-only proteins BID and PUMA inhibits tumorigenesis in some settings (Berardo et al., 1998; Biswas et al., 2013; Labi et al., 2010; Michalak et al., 2010; Reed, 1996).