Meanwhile, the average of serum Sdc1 in NC and DM group were 12.2 ± 0.788 ng/ml and 22.2 ± 1.01 ng/ml (P = 4.97 × 10−6, Fig.1D), serum HPSE were 364.3 ± 43.3 mU/ml and 961.8 ± 73.0 mU/ml (P = 1.35 × 10−5, Fig.1E) respectively, both exhibiting notable elevations in DM groups. This evidence concerns the gene SDC1 and diabetes mellitus.