In the diabetic group (DM), tissue Sdc1 from small-intestinal samples was significantly lower (1.002 ± 0.076 versus 0.510 ± 0.065, P = 0.002, Fig.1A), but qRT-PCR showed no significant changes of Sdc1 mRNA when compared with NC (1.062 ± 0.106 versus 1.350 ± 0.149, P = 0.159, Fig.1B), which indicated the decreases of Sdc1 protein derived from the destruction after its synthesis. Here, SDC1 is linked to diabetes mellitus.