GPNMB and neoplasm: In accordance with their multi-functional tumor-promoting capacity, SS-TAMs were further found to highly express genes with capacity to promote angiogenesis and matrix remodeling (Table 1; Figures 4B and S3C), including transcripts encoding MMP2, 3, and 12, TIMP-2, CD13, galectin-3, heme oxygenase-1, and GPNMB, which are strongly implicated in these processes [27–30].