In order to better understand the therapeutic potential of RG7116, we further assessed the anti-tumoral efficacy mediated by HER3-signaling inhibition in a FaDu cell line-based xenograft of human hypopharyngeal cancer and characterized the PK and PD changes occurring in response to treatment with RG7116 at different doses and dosing schedules. The gene discussed is ERBB3; the disease is hypopharynx cancer.