LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: Consistent with the pattern of activity of Enh-B, hs1371 and hs1643, MR imaging in ADLD-1-TO patients showed that forebrain-derived structures are affected, but the cerebellum (hindbrain-derived) is spared, a telling difference with ADLD families with LMNB1 duplication, where WM throughout the brain degenerates (20,21).