HT29CaSR-DN and Caco2-15CaSR-DN cells expressed the receptor at the cell surface [46], however they were resistant to the tumor protective actions of Ca2 + consistent with previous findings that the residue R185 lies in close proximity to one of the proposed Ca2 + binding sites [47], and that dimerization of mutant R185Q with wild-type CaSR reduces functionality of the latter [46]. This evidence concerns the gene CASR and neoplasm.