The largest NOD2/CARD15 study to date, 567 donor-recipient pairs both HLA matched and mismatched with primary diagnoses including hematologic malignancies, non-hematologic malignancies, and nonmalignant diseases, found only a borderline association (p = .049) of a recipient SNP with increased TRM and conflicting results in the non-malignant patient groups [60]. This evidence concerns the gene NOD2 and hematologic disorder.