For example, an analysis of 35 patients with thyroid papillary carcinoma and 11 of metastatic lymph nodes showed a significantly reduced level of the NME1 mRNA in metastatic lymph nodes, whereas NME2 mRNA was not changed in the original tumor and lymph nodes [14], suggesting differential roles of NME1 and NME2 in cancer invasion and metastasis. This evidence concerns the gene NME1 and differentiated thyroid carcinoma.