Although it is tempting to speculate a direct role for KIR2DL2, KIR2DL3, KIR2DS3 and KIR2DS5 in HCV-related lymphoproliferations, it is likely that these genes are all surrogate markers of the same KIR genotype found at a higher frequency in HCV-related lymphoproliferations compared to CHC cases (genotype ID number 4, Fig. 1A and B). The gene discussed is KIR2DL3; the disease is cryohydrocytosis.