As regard the KIR2DS3 gene found associated with CHC (Fig. 1C), an analysis of the telomeric/centromeric regions showed that the region including both the 2DS3 and the KIR2DS5 genes (Cent/Tel1) was mostly reduced in lymphoproliferative disorders patients, while the motif excluding the KIR2DS5 gene (Cent/Tel3) was more reduced in HCC patients (Table 2, Fig. 3). The gene discussed is ETV6; the disease is cryohydrocytosis.