KIR2DS4 and cryohydrocytosis: The KIR3DL1-KIR2DS4 block is part of a conserved genotype termed “ancestral genotype.” The presence of both the KIR3DL1 gene and the deleted form of the KIR2DS4 gene (KIR2DS4 del variant, Tel-2DS4 (3), Table 3), which generates a premature stop codon, revealed a frequency higher in HCC cases (70.3%) compared to CHC cases (52.0%, p < 0.01, Fig. 3F).