Our study results support this association: we found: (i) a higher frequency of KIR3DL1 and KIR2DS4 genes, both representative of the AA-genotype characterized by a reduction of activator KIR genes [48] in HCC cases than in CHC cases (Fig. 1C) and (ii) an association of HCC with the presence of KIR3DL1 and deleted nonfunctional variant of the KIR2DS4D gene, the unique activator gene presents in the AA-genotype (Tel-2DS4 (3), Table 3 and Fig. 3F). The gene discussed is KIR2DS4; the disease is cryohydrocytosis.