In the prevention-study, echocardiography and cardiac catheterisation (Fig. 2C and D, and S2 Fig.: A, C, E and G) as well as histomorphology of the hearts (Table 1) of untreated vs. treated animals revealed that both bisoprolol and β1EC2-CP were able to prevent development of cardiomyopathy and heart failure. This evidence concerns the gene CP and heart failure.