Supplementation of the selective NOS2 inhibitor N-(3-(Aminomethyl)benzyl)acetamidine (1400W) [242], did not affect systemic hemodynamic parameters during prolonged hyperdynamic porcine endotoxemia [243], however was capable of attenuating the impaired intestinal oxygenation and energy state [162]. This evidence concerns the gene NOS2 and serum lipopolysaccharide activity.