Indeed, the different time points of peak expression of NOS2 and arginase in murine endotoxemia models, after, respectively, 20 min, 4–6 h and 12 h for NOS2 [153] and 12–36 h for arginase may indicate this inhibitory effect [142,192,193,194]. This evidence concerns the gene NOS2 and serum lipopolysaccharide activity.