BRCA2 and cancer: Similarly, the implications of a proposed role for BRCA2 in transcription-associated recombination (TAR) and in the processing of R-loops in partnership with RNA processing factors suggest that these structures are a source of cancer-related instability (Bhatia et al., 2014, Gallardo et al., 2003, Huertas and Aguilera, 2003, Savolainen and Helleday, 2009).