In addition, inositol hexakisphosphate kinase type 2 (InsP6K2) was reported to induce autophagy, a protein aggregate clearance process in HD patients, and apoptotic cell death concomitantly, possibly via the Akt/phosphatidylinositol 1,4,5-trisphosphate pathway in HD lymphoblast or mutant HTT transfected cells [39,40]. Here, IP6K2 is linked to Huntington disease.