We observed significantly higher concentrations of NGAL in umbilical cord blood of children with HLHS compared with controls (91.1 ng/mL, 95% CI: 35.9–152.4 ng/mL versus 31.0 ng/mL, 95% CI: 22.9–36.4 ng/mL; P < 0.001). The gene discussed is LCN2; the disease is hypoplastic left heart syndrome.