MMP14, MMP2, and MMP9 have all been shown to be important in cancer progression and enriched at the invadopodia (Monsky et al., 1993; Nakahara et al., 1997; Bourguignon et al., 1998; Artym et al., 2006; Clark and Weaver, 2008; Poincloux et al., 2009). The gene discussed is MMP2; the disease is cancer.