NFE2L2 and breast carcinoma: For instance, several phase II enzymes under Nrf2 control have been overexpressed in cancer cells; HO-1 overexpression was present in prostate and brain cancer beside renal cancer (Goodman et al., 1997); NQO1 upregulation was detected in hepatoblastoma, colon cancer, breast cancer, and non-small cell lung cancer (Maines and Abrahamsson, 1996).