CYBB and chronic granulomatous disease: A 369Cys to Arg mutation in Nox2 causes chronic granulomatous disease (CGD) of the X91+ form, with normal expression of Nox2 but impaired production of O·−2, impaired translocation of cytosolic components, and low FAD binding (Leusen et al., 2000; Debeurme et al., 2010).