This reduced expression is associated with constitutive activation of MAPK1/ERK2 and, despite the presence of mutated KRAS, exogenous overexpression of DUSP6 induces dephosphorylation of MAPK1/ERK2, subsequent suppression of proliferation, and eventual apoptosis of pancreatic cancer cells (16). Here, KRAS is linked to familial pancreatic carcinoma.