ESR2 and colorectal carcinoma: Furthermore, members of p160 ER co-activator superfamily AIB1 (SRC-3/NCoA3) and TIF2 (SRC-2), which interact with ERβ to mediate transcriptional activity, were up-regulated in adenomas and carcinomas compared to normal tissue; AIB1 was also associated with increased overall survival in a cohort of 110 CRC patients (62).