RARRES2 and obesity due to melanocortin 4 receptor deficiency: The possibility that chemerin plays a role in metabolic disease, in particular with obesity and type 2 diabetes, arose when it was discovered that adipose tissue is one of the main tissues from which chemerin is secreted (i.e., it is an adipokine), and that circulating levels in humans correlate with body mass index, plasma triglycerides and blood pressure (Ernst & Sinal, 2010).