RARRES2 and obesity due to melanocortin 4 receptor deficiency: Chemerin stimulates adipogenesis and angiogenesis (Bozaoglu et al., 2010; Goralski et al., 2007), so the possibility that its absence may restrict the ability of adipocytes to expand and act as a ‘sink’ for glucose was considered as a mechanism for impaired glucose homeostasis in the absence of obesity.