CD4 and infection: The infection of the antigen presenting dendritic cells [83–86] and profound bystander apoptosis of lymphocytes [63, 87–89] impairs the development of adaptive immunity [90, 91] and EBOV-specific CD8+ T [92–94], as well as CD4+ T cells [95] that are important for the clearance of, and protection from, the EBOV infection.