CRP and laryngotracheoesophageal cleft: The assumption of a greater inflammatory response associated with the open surgical method, is further enhanced by the statistically significant increase found in both erythrocyte sedimentation rate (ESR) 24 h postoperatively (P < 0.02) [12] and C-reactive protein (CRP) values on the first (P < 0.003) [12] and on the second postoperative day (P < 0.04) [12] for the OC compared to the LC patients, taking into account that CRP is considered to be a sensitive indicator of the inflammation [35].