Nutlin-3a, murine double minute 2 (MDM2) inhibitor, destabilises the complex formed by the MDM2, p53, and KSHV latency-associated nuclear antigen (LANA), which triggers large-scale apoptosis in KSHV-induced primary effusion lymphoma (PEL) cells [124]. This evidence concerns the gene MDM2 and primary effusion lymphoma.