TUBB and non-small cell lung carcinoma: In another study, 65 NSCLC patients taking preoperative carboplatin and paclitaxel and a group of 53 NSCLC patients treated with surgery alone showed no statistically significant change between primary and rebiopsy material of lung tumors in class-III-beta-tubulin expression, which may be a potential predictive factor for microtubule interfering cytotoxic drug treatment [9].