ERBB2 and neoplasm: More recently, a double-blind placebo-controlled international multicentre clinical trial (CLEOPATRA)designed to evaluate the efficacy and safety of pertuzumab+trastuzumab+docetaxel (pertuzumab arm) versus placebo+trastuzumab+docetaxel (control arm) showed a survival improvement in the pertuzumab arm and also demonstrated that ErbB2 marker is suited for patient selection for the pertuzumab-based regimen in ErbB2-positive metastatic breast cancer or locally recurrent unresectable tumor (Baselga et al., 2014; Fleeman et al., 2015).