The most investigated ERBB2 polymorphism related to cancer risk is I655V (rs1136201) located at the codon 655 (ATC/isoleucine to GTC/valine) in the transmembrane domain of the receptor (Figure 1, Supplemental Table 2) (Kuraoka et al., 2003; Puputti et al., 2006; Han et al., 2014). The gene discussed is ERBB2; the disease is cancer.