NCR3 and B-cell chronic lymphocytic leukemia: In line, an impaired expression of ligands for two major activating receptors—NKG2D and NKp30—was shown to be associated with CLL probably explaining NK cell anergy in this disease (Figure 1; Salih et al., 2008; Nuckel et al., 2010; Costello et al., 2012; Reiners et al., 2013).