CXCL12 and B-cell chronic lymphocytic leukemia: NLC attract CLL cells by secreting CXCL12 and CXCL13 and protect from drug induced apoptosis via CXCL12, BAFF, APRIL, CD31, and plexin-B via activation of prosurvival cascades such as NFκB and ERK (Burger and Gribben, 2014).