Interestingly, DAMP molecules such as high-mobility group protein B1 and S100A8/9 have the ability to bind heparin sulfate and HSPGs, which are known to be co-ligands involved in NCR-dependent recognition of tumor cells resulting in secretion of IFN-γ but not cytotoxicity (49, 50, 67). Here, IFNG is linked to neoplasm.