TP53 and neoplasm: One HDI, suberoylanilide hydroxamic acid (SAHA), suppressed tumor growth, invasion, and migration of highly aggressive ovarian carcinomas by modulating a variety of phenotype-related molecules including members of the caspase pathway, the cell cycle regulator Cyclin B1, tumor-suppressor genes (p21, p53), and tissue remodeling MMP-9 enzyme, among others (46).