In 1994, Weber et al. found that 40–50% of tissue samples obtained from patients with advanced melanoma were positive for MAGE-1 from both early and metastatic stages while a wide range of normal tissue samples including tumor-infiltrating lymphocytes, peripheral blood from patients with metastatic melanoma, melanocytes, and benign nevus showed no expression of MAGE-1. The gene discussed is MAGEA1; the disease is metastatic melanoma.