FHL1 and age-related macular degeneration: Because such highly sulfated sequences are rare within the human Bruch’s membrane (BM) (an extracellular matrix of the eye), this might be the underlying cause of why complement dysregulation occurs at this site; i.e., due to insufficient FH/FHL-1 binding in 402H individuals (20, 22), leading to local inflammation that drives AMD pathology.