Different studies associated the increased serum/plasma sHLA-G levels with hepatitis B virus infection (33, 95, 96), which were associated with increased percentage of CD4+CD25+FoxP3+ T regulatory and HLA-G+CD14+ monocytes cells in patients exhibiting acute or chronic hepatitis (95), active hepatitis B virus infection (33) and HBeAg negative hepatitis, hepatocellular carcinoma, and increased alanine aminotransferase levels (96). Here, CD4 is linked to hepatitis B virus infection.