Increased HLA-G expression has been observed in different tumor types, including breast cancer (22–29), hepatocellular carcinoma (30–33), papillary thyroid carcinoma (34, 35), follicular thyroid carcinoma (35), follicular adenoma (35), nasopharyngeal carcinoma (36), neuroblastoma (37), bladder transitional cell carcinoma (TCC) (38), melanoma (39–42), colorectal cancer (43–45), gastric cancer (46–48), esophageal carcinoma (49–53), lung cancer (49, 54–57), renal cell carcinoma (58–62), glioblastoma (63–66), acute myeloid leukemia (67, 68), and B-cell chronic lymphocytic leukemia (69–73). The gene discussed is HLA-G; the disease is melanoma.