HLA-G and neoplasm: In most tumors, the increased HLA-G expression has been associated with advanced disease stages, shorter survival time, presence of metastasis, higher tumor grade, weak host immune response, greater tumor size, tumor recurrence, tumor invasion, poor histological grade, lower classical HLA antigen expression, presence of infiltrating T regulatory cells, cancer progression, increased inflammatory cell lesion infiltration, and tumor differentiation (23, 24, 26, 29–32, 34–36, 40–42, 44, 46–48, 50–54, 56, 57, 66, 69, 72, 73, 79).