In a tumor model, activated OT-I cells were also responsible for the deep infiltration and accumulation of activated non-specific T cells in OVA-expressing EL4 tumors (Boissonnas et al., 2007), indicating that CD8+ T cells not only exert a direct cytotoxic activity on target cells, but can also orchestrate a focal inflammatory response by the recognition of a specific antigen and further recruitment of specific and non-specific T cells to the site of infection or tumor growth. Here, CD8A is linked to infection.