ADRB2 and myocardial infarction: It also should be noted that much like patients prone to SCD (Rubart and Zipes, 2005), post-MI VF-susceptible dogs have well-documented abnormalities in myocardial calcium handling, being characterized by leaky and oxydized ryanodine receptors (Belevych et al., 2009) as well as increased calcium (Ca2+) entry and Ca2+ transients, particularly during β-AR stimulation (Billman et al., 1997; Altschuld and Billman, 2000; Belevych et al., 2012).