ICa,L and ICa,T play a major role in atrioventricular conduction as underscored by the presence of dissociated rhythms in Cav1.3−/− mice and SANDD patients (Baig et al., 2011) or in Cav1.3−/−/Cav3.1−/− mice and CHB patients (Marger et al., 2011a). Here, CACNA1G is linked to sinoatrial node dysfunction and deafness.