CCN2 and Ureteral obstruction: As already reported (Morrissey et al., 1996; Klahr, 2000; Chevalier et al., 2009; Duffield, 2014), we confirmed the up- or down-regulation of several genes involved in the renal fibrotic process following ureteral obstruction such as Tgfb1, Ctgf, collagens types (I, III, IV), fibronectin, Nfkb, growth factors, chemokines, etc... We also confirmed at the tissue level the antifibrotic effect of AT1a (Ishidoya et al., 1995) and B1Ra (Klein et al., 2009).