PANX2 and central nervous system cancer: Human Panx2 DNA is located in the same chromosomal regions that are implicated in human gliomas (Ino et al., 1999; Oskam et al., 2000; Hu et al., 2004) and exogenous Panx2 transfected into rat C6 glioma cells displayed a flattened morphology and increased cell–cell contacts and significantly reduced in vitro oncogenicity parameters (Lai et al., 2009).