IGHE and parasitic infectious disease: Helminthes infections will active prominent Th2-type cytokines and immune regulatory processes [23] and chronic geo-helminthes infection with high total IgE and anti-Ascaris IgG4 may reduce the risk of atopy in school-age children [38], but parasite infections do not in general protect against asthma while hookworm infection may reduce the risk of this disease [39].