Here, in children exposed to and infected with several parasite species not only regulatory IL-10 and anti-inflammatory IL-27 was produced by their PBMC, but also pro-inflammatory IL-33, MIP-3a/CCL20 and MIG/CXCL9 responses were observed, and with an increasing number of parasite infections these pro-inflammatory cytokines and chemokines responses enhanced. This evidence concerns the gene IL33 and parasitic infectious disease.