Since only human pDCs and B-cells express high levels of TLR7 and TLR9 [28] and both cell types are involved in the pathophysiology of SLE, we also explored the inhibitory potential of G-modified INH-ODNs on human B-cells stimulated via TLR7 or TLR9. The gene discussed is TLR9; the disease is systemic lupus erythematosus.