Mutations in lamin A/C [20,21], peroxisome proliferator-activated receptor-γ (PPARγ) [22], fat-specific protein 27-kDa (Fsp27/Cidec) [23] and perilipin 1 (Plin1) [12] lead to partial lipodystrophy. The gene discussed is PLIN1; the disease is partial lipodystrophy.