PLIN1 and partial lipodystrophy: This phenomenon suggests that Plin1 haploinsufficiency inhibit the droplet formation and adipogenesis, providing a cellular basis for the pathology of smaller-than normal adipocytes and partial lipodystrophy in patients with heterozygous Plin1 mutations [12].The differentiation of adipocytes precursors in primary culture is under the influence of many physiological factors [51].