In addition, expression of BCL2L1 was dependent on mutant p53 in SKBR3 mammary adenocarcinoma cells expressing p53R 175H, and in HT29 human colorectal adenocarcinoma cells expressing p53 R273H, another p53 mutant with gain-of-function activities [63]. Here, TP53 is linked to colorectal adenocarcinoma.