Interestingly, the data from this study demonstrated that MMTV-Hras/p53R172H/R172H and MMTV-Hras/p53-/- mice are very similar with regard to age of salivary tumor onset, tumor growth rates, tumor histopathological features, and response to a DNA-damaging agent, doxorubicin. Here, HRAS is linked to neoplasm.