HRAS and neoplasm: In the current study, we have included p53 R172H as the third p53 status in this tumor model by crossing the MMTV-Hras mice to p53 R172H knock-in mice [46], and have performed head-to-head comparisons of the effects of the three classes of p53 status on salivary tumorigenesis, tumor properties, and tumor response to doxorubicin.