Xu et al (19) found that targeting STAT3 with STAT3 small interfering (si)RNA inhibited MCF-7 breast cancer cell proliferation induced by Jak/STAT and PI3K/Akt pathways, as transfection with STAT3 siRNA blocked not only STAT3 expression but also Akt expression. The gene discussed is AKT1; the disease is breast carcinoma.