However, transfection with ectogenic genes through adenovirus vectors enabled stable SCOS3 expression at the protein level, and therefore, through in vivo and in vitro study, it was found that SOCS3 inhibited the proliferation and angiogenesis of SCLC cells and these biological effects were achieved through the regulation of HIF-1α expression. The gene discussed is HIF1A; the disease is small cell lung carcinoma.