GRHL1 and neoplasm: For example, HDAC1 in the sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents,35 HDAC2 in repressing miR-183-mediated tumor suppression36 and HDAC3 in negatively regulating tumor suppressor GRHL1.37 Recently, we have discovered a novel function for HDAC10 in promoting autophagy-mediated cell survival.