HDAC8 and neuroblastoma: One already well-known result of retinoic acid treatment in neuroblastoma is the reduction of MYCN oncogene expression in amplified tumors.21 Interestingly, the cotreatment with HDAC8-selective inhibitors even further reduced MYCN protein levels in BE(2)-C and IMR-32 cells (Figure 5f and Supplementary Figure S3F).